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3-dioxygenase (IDO1) inhibitor with IC50 ~10 nM It displays high selectivity over other related enzymes such as IDO2 or tryptophan 2
and strains of Haemophilus and Listeria at concentrations of less than 3
22(4):537-50
The ability of the C3 amide to fit and bind to this pocket is believed to be a key source of kinome selectivity for TyK2-IN-2 (Compoud 18)
a potent chelator of iron
PF-3450074 60276 3-dioxygenase (IDO1) inhibitor with IC50PF 3450074 (PF 74) is a specifical inhibitor of HIV 1 capsid protein (CA) and displays a broad spectrum inhibition of HIV isolates with submicromolar potency (EC50=8 640 nM). PF 3450074 (PF 74) acts at an early stage of HIV 1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors
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